Achieving global goals for poverty reduction, economic growth and environmental health will require widespread innovation and implementation of new and appropriate “green growth” technologies. Establishing a sufficiently large suite of innovative options, suitable to all economies, and at the urgent pace required will involve unprecedented innovation activity not only from developed regions, but also from new clusters and enterprises in emerging economies and least developed countries. Stronger international cooperation can play a critical role in facilitating this transformative process. In this paper, we look at areas for new partnerships or cooperation that could most effectively accelerate a green growth transformation. We do this by reviewing the components of a successful innovation “ecosystem,” assessing the current status and prospects for green growth innovation, compiling and analyzing existing international initiatives, assessing the needs and pragmatic constraints on international institutions, and recommending an integrated approach to spur global green growth innovation partnerships, especially within developing countries.